Isoflavones block uptake of dietary cholesterol by macrophages in mice, but fail to cause a reduction of artherosclerosis.
"Soy protein containing isoflavones favorably influences macrophage lipoprotein metabolism but not the development of atherosclerosis in CETP transgenic mice."
How can they say that this had a favorable influence? If lowered uptake of cholesterol by macrophages had no benefit to the mice? ?
If you remove a mouse's ovaries, then feed her cholesterol, she gets artherosclerosis.
If you remove a dog's thyroid, and feed it cholesterol, artherosclerosis.
If you feed a bunny cholesterol, it gets artherosclerosis. This after all you did was add cholesterol to it's natural diet of corn starch cellulose and caseine protein. But if you make the rabbit type I diabetic by removing its pancreas, it fails to get artherosclerosis. Still in trouble, just no artherosclerosis. In other studies they avoided bunny heart disease by feeding them dessicated thyroid. In still other studies they just fed them iodine, and that worked against artherosclerosis.
A rabbit's natural diet is grass, bark, twigs. Grass is a rich source of vitamin k, beta carotene, and being a green vegetable, probably iodine. Did a multi-billion dollar statin industry grow out of studies on iodine-deficient rodents?
If you wanna avoid heart disease, get your hormones sorted out.
(The fact that women are less likely to get heart disease but more likely to get goiter--that's kind of suggestive, ain't it?)